Clinical and CT imaging features of the COVID-19 pneumonia: Focus on pregnant women and children

Liu H, Liu F, Li J, Zhang T, Wang D, Lan W. Clinical and CT imaging features of the COVID-19 pneumonia: Focus on pregnant women and children. J Infect. 2020;80(5):e7‐e13. doi:10.1016/j.jinf.2020.03.007

Review written by:

Gabriel Pomerantz, edited by Elizabeth Harty

Red - The study’s small sample size, low-dose technique and its inconsistency reporting on subjects may impact the validity of the results.

59 patients’ clinical and chest CT features were evaluated. From the 59 patients, 41 were pregnant women, 4 were children and 14 were non-pregnant adults (women and men). From the 41 pregnant women, 16 were pregnant women with laboratory confirmation of infection by COVID-19, 17 had a negative COVID-19 laboratory test but had typical COVID-19 imaging features and 8 didn’t have a laboratory test.

Clinical features: fever was present in all the non-pregnant participants but was seen less frequently in the pregnant groups. No pregnant women were admitted to the ICU.

Laboratory results: leukocytosis and elevated neutrophil ratio were more frequent in the pregnant groups than in the non-pregnant group.

Imaging results: all groups had the same peripheral distribution of the lesions. In the pregnant groups, the most frequent lesions were consolidated ground glass opacity-like and consolidation. In the non-pregnant group, the most frequent lesions were ground glass opacity and ground glass opacity with reticulation. All groups had a mean of 3 lung segments involved.

Follow-up: 54% of pregnant women didn’t perform the follow-up CT scan.

Children: Clinical features were mixed. Their imaging results were also mixed with normal findings to multiple focal consolidation lesions and pleural effusion.

Review Notes

1.  Small sample size and inclusion of men in the non-pregnant women.

2. Selection bias associated with the majority of subjects being selected from a women and children’s hospital.

3. 54% of pregnant women were not present for follow-up CT imaging.

4.  Low-dose imaging technique resulted in poor resolution capture

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